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VOL. 13, ISSUE 2 (2026)
Design, optimization and characterization of a prebiotic-integrated Albendazole mouth dissolving film utilizing mixed Hydrotropy for enhanced drug solubility and gastrointestinal absorption
Authors
Upadhyay Nikita, Mishra Rajshree
Abstract
Albendazole is a
broad-spectrum anthelmintic drug widely used for the treatment of parasitic
infections. However, its therapeutic effectiveness is limited by poor aqueous
solubility and low gastrointestinal absorption, resulting in reduced
bioavailability. The present review focuses on the development of a
prebiotic-integrated albendazole mouth dissolving film using mixed hydrotropy
to enhance drug solubility and gastrointestinal absorption. Mixed hydrotropic solubilization
offers a safe and efficient approach for improving solubility without the use
of toxic organic solvents. The integration of prebiotic polymers such as inulin
and fructooligo saccharides improves intestinal microflora balance and enhances
drug absorption. Mouth dissolving film technology provides rapid drug release,
improved patient compliance, and avoidance of first-pass metabolism. Various
formulation parameters, optimization techniques, and characterization methods
such as drug content, folding endurance, disintegration time, and dissolution
studies are discussed. The review highlights the potential of combining
hydrotropic solubilization and prebiotic integration as an innovative strategy
for improving albendazole bioavailability.
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Pages:1-4
How to cite this article:
Upadhyay Nikita, Mishra Rajshree "Design, optimization and characterization of a prebiotic-integrated Albendazole mouth dissolving film utilizing mixed Hydrotropy for enhanced drug solubility and gastrointestinal absorption". International Journal of Multidisciplinary Research and Development, Vol 13, Issue 2, 2026, Pages 1-4
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