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VOL. 13, ISSUE 1 (2026)
Decoding the molecular symphony of CSTX of Cupiennius Salei spider using an approach of bioinformatics
Authors
Dr. Parakh Sehgal, Dr. Chetna Rahangdale
Abstract
Spider venoms are
complex mixtures of bioactive molecules with important ecological roles and
growing biomedical interest. This study focuses on CSTX (Cupiennin Spider
Toxin) peptides from Cupiennius salei and explores their structural and
evolutionary characteristics using bioinformatics approaches. This study places
CSTX peptides within a broader venom biology framework by interpreting their
structural and physicochemical features in the context of the multicomponent
nature of spider venom. CSTX peptides are discussed alongside enzymatic
components such as hyaluronidases and proteases that facilitate tissue
penetration and venom dissemination, as well as polyamines and small bioactive
molecules that modulate neuronal signaling and enhance venom efficacy. In
addition, the membrane-active and amphipathic characteristics of CSTX are
considered in relation to antimicrobial peptides present in spider venoms,
highlighting shared mechanisms of membrane disruption and cytolytic activity.
Sequence retrieval, physicochemical profiling, secondary and three-dimensional
structure prediction, and phylogenetic analysis were carried out to understand
the diversity and organization of CSTX peptides. Together, this integrative
perspective emphasizes spider venom as a coordinated biochemical system and
situates CSTX within a wider evolutionary and functional context rather than as
an isolated toxin. Overall, the findings highlight the structural conservation
and functional diversity of CSTX peptides and emphasize spider venom as a
promising natural resource for future research.
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Pages:116-122
How to cite this article:
Dr. Parakh Sehgal, Dr. Chetna Rahangdale "Decoding the molecular symphony of CSTX of <i>Cupiennius Salei</i> spider using an approach of bioinformatics". International Journal of Multidisciplinary Research and Development, Vol 13, Issue 1, 2026, Pages 116-122
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