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VOL. 13, ISSUE 1 (2026)
Evaluation of antioxidant and antidiabetic potential of different plants of Justicia adhatoda L
Authors
Rajani Choudhary, Shiv Kumar Singh
Abstract
Medicinal plants are a valuable source of bioactive compounds with
therapeutic potential against oxidative stress–related disorders and metabolic
diseases such as diabetes mellitus. Justicia adhatoda L. is a well-known
medicinal plant traditionally used for the treatment of respiratory ailments, inflammation,
and metabolic disorders. The present study aimed to evaluate the antioxidant
and antidiabetic potential of different parts (stem, leaves, and flowers) of J.
adhatoda extracted using solvents of varying polarity, namely water,
ethanol, and n-hexane. Antioxidant activity was assessed using the DPPH free
radical scavenging assay, while antidiabetic potential was evaluated through
α-amylase inhibition using the DNSA method. All extracts exhibited
dose-dependent activity in both assays. Among the solvents tested, ethanolic
extracts generally demonstrated superior antioxidant and antidiabetic
potential, as indicated by lower IC₅₀ values, followed by aqueous and hexane
extracts. Variation in bioactivity among different plant parts highlights the
influence of solvent polarity and phytochemical composition on biological
efficacy. The findings of the present study substantiate the traditional use of
J. adhatoda and suggest its potential as a natural source of antioxidant
and antidiabetic agents for further pharmacological and clinical
investigations.
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Pages:101-104
How to cite this article:
Rajani Choudhary, Shiv Kumar Singh "Evaluation of antioxidant and antidiabetic potential of different plants of <i>Justicia adhatoda </i>L". International Journal of Multidisciplinary Research and Development, Vol 13, Issue 1, 2026, Pages 101-104
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