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VOL. 12, ISSUE 2 (2025)
The relationship between thyroid functions and blood parameters in patients with renal failure
Authors
Zainab A Shehab, Zahraa Aqeel Shihab, Ibtihal Hassan Hatim
Abstract
Renal function is significantly impacted by
both hypothyroidism and hyperthyroidism. Despite this, there is a lack of
clinical research examining the relationship between thyroid dysfunction and
renal function. This study aimed to assess alterations in biochemical
indicators of renal function in individuals with thyroid dysfunction and to
establish a connection between these values and the patient's thyroid profile. Additionally,
the impact of changes in thyroid function on renal function during treatment
was explored. Various interactions exist between the functions of the thyroid
and kidneys in the presence of disease. Thyroid hormones have a significant
impact on the development and function of the kidneys, causing changes in renal
blood flow and glomerular filtration rate (GFR) both before and within the
kidneys. A decrease in GFR is seen in individuals with hypothyroidism, while
those with hyperthyroidism experience an increase in GFR, as well as heightened
activation of the renin-angiotensin-aldosterone system. In the context of
chronic kidney disease (CKD), a medical phenomenon known as low T3 syndrome has
been acknowledged as a distinct presentation of nonthyroidal illness. It has
been observed that individuals with chronic kidney disease frequently exhibit a
higher incidence of primary hypothyroidism and subclinical hypothyroidism. The
potential advantages of a hypothyroid condition in chronic kidney disease,
coupled with the increased risk of disease advancement with hyperthyroidism,
underscore the importance of a cautious strategy when managing thyroid hormone
irregularities in this patient group. Thyroid dysfunction is commonly
associated with glomerulonephritis, a condition often attributed to an
autoimmune etiology. Specific medications can affect the functions of both the
thyroid and kidneys. Although interactions involving thyroid and renal
malignancies have been reported minimally, it is imperative for nephrologists
and endocrinologists to possess a thorough understanding of these connections
in order to provide optimal care for patients.
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Pages:46-51
How to cite this article:
Zainab A Shehab, Zahraa Aqeel Shihab, Ibtihal Hassan Hatim "The relationship between thyroid functions and blood parameters in patients with renal failure". International Journal of Multidisciplinary Research and Development, Vol 12, Issue 2, 2025, Pages 46-51
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