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VOL. 12, ISSUE 12 (2025)
Ultraviolet light causes skin cell senescence
Authors
Sunita Nagpal
Abstract
The skin serves as a strong barrier that keeps
the body safe from harm brought on by the environment. Additionally, skin
health has a big impact on outward appearance. Skincare and wellbeing are
receiving more attention in this day and age of material and spiritual wealth.
One of the most frequent external causes of diseases including sunburn, skin
cancer, and skin ageing is ultraviolet radiation. Skin cell senescence, a kind
of ageing marked by cell cycle halt and impaired cellular function, can be brought
on by ultraviolet [UV] radiation, mainly UVA and UVB. DNA damage, oxidative
stress, and inflammatory reactions are the main causes of this senescence,
which eventually leads to skin ageing and may raise the risk of skin cancer.
The main goal of prevention techniques is to reduce UV exposure by using
sunscreen, protective clothes, and diets high in antioxidants. This article
discusses a number of UV-induced skin cell senescence processes, each with
unique traits and reciprocal effects, such as DNA damage, oxidative stress,
inflammatory response, and mitochondrial failure. For example, oxidative stress
and the activation of the NLRP3 inflammasome result from mitochondrial
malfunction, which also causes electron evasion and the production of
additional reactive oxygen species, which damages mitochondrial DNA [mt DNA].
According to the current methodology, effective preventative and therapeutic
measures are suggested for sunscreen, nutrition, and experimental drugs,
respectively, with the goal of delaying the ageing of skin cells and offering
UV protection. Insights and recommendations for future research on the
mechanism of skin cell senescence are provided, along with a summary of the
effects of UV radiation on skin in the hopes of finding better preventative and
therapeutic measures. Senescent cell ablation has so far only been demonstrated
to have a positive impact on skin ageing in transgenic mouse models or after
more general therapies. We conclude that there is strong but not yet absolute
evidence that cellular senescence is a significant contributor to intrinsic
skin ageing.
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Pages:146-149
How to cite this article:
Sunita Nagpal "Ultraviolet light causes skin cell senescence". International Journal of Multidisciplinary Research and Development, Vol 12, Issue 12, 2025, Pages 146-149
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