Background: Stroke frequently leads to upper extremity motor impairment, which limits functional independence and activities of daily living. Modified Constraint-Induced Movement Therapy (mCIMT) promotes use of the affected limb by restricting the unaffected limb, while Task-Oriented Training (TOT) emphasizes purposeful, goal-directed activities that enhance neuroplasticity and motor recovery. This study evaluated the combined effect of mCIMT and TOT on upper limb function in patients with sub-acute stroke.

Methods: Twenty-eight patients with sub-acute middle cerebral artery stroke (1 month to 1-year post-onset) were randomly allocated into two groups (n = 14 each). The experimental group received mCIMT combined with Task-Oriented Training, while the control group received conventional physiotherapy. Both groups received 1-hour sessions, 5 days/week, for 4 weeks. Upper limb motor function and functional performance were assessed pre- and post-intervention using the Fugl-Meyer Assessment for Upper Extremity (FMA-UE) and the Action Research Arm Test (ARAT). Data were analyzed using paired and independent t-tests, with p < 0.05 considered significant.

Results: The experimental group showed statistically and clinically significant improvements. Mean FMA-UE scores increased from 24.85 to 39.14, and ARAT scores from 14.71 to 26.71. The control group showed modest gains (FMA-UE: 22.07 to 23.92; ARAT: 11.21 to 12.28). Between-group differences in post-treatment FMA-UE and ARAT scores were significant (p < 0.05), favouring the experimental group.