ARCHIVES
VOL. 12, ISSUE 1 (2025)
Physiological study of prednisolone and dexamethasone and their effect on calcium and vitamin D metabolism in laboratory animals
Authors
Zainab A Shehab, Ibtihal Hassan Hatim, Zahraa Aqeel Shihab
Abstract
In recent years, there has been a significant
amount of focus research on the deficiency of vitamin/hormone D, a thorough
examination has been carried out regarding recommendations, guidelines, and
treatments. Furthermore, vitamin D has been firmly established as a hormone in
numerous enzymatic, metabolic, physiological, and pathophysiological processes
that impact various organs and systems within the human body. The growing
attention to this topic is due to the common occurrence of mild to severe
vitamin D deficiency on a global scale. It is widely acknowledged that
maintaining optimal vitamin D levels is crucial for the health of bones,
muscles, overall well-being, and the effectiveness of treatments aimed at
preventing bone loss and promoting bone formation. Currently, vitamin D, along
with vitamin D supplementation, is being used to increase vitamin D levels and
correct deficiencies. This review delves into the established and emerging
principles regarding the metabolism of vitamin D/hormone D, sources in the
diet, concerns about deficiency, as well as the various types of vitamin D
supplements available in the market and the optimal strategies for their use. Moreover,
research involving knockout and transgenic mice has offered fresh perspective
on the biological function of vitamin D in traditional target tissues, in
addition to showcasing the possible non-skeletal impacts of 1,25(OH)2D3 such as
hindering cancer advancement, influencing the cardiovascular system, and
modulating the immune response in specific autoimmune conditions. Several
discoveries on a molecular level in mouse models have mirrored results seen in
human subjects. The recognition of comparable pathways in humans holds the
potential for the creation of innovative treatments for disease prevention and
management.
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Pages:37-43
How to cite this article:
Zainab A Shehab, Ibtihal Hassan Hatim, Zahraa Aqeel Shihab "Physiological study of prednisolone and dexamethasone and their effect on calcium and vitamin D metabolism in laboratory animals". International Journal of Multidisciplinary Research and Development, Vol 12, Issue 1, 2025, Pages 37-43
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