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VOL. 11, ISSUE 6 (2024)
Relationship analysis of radiation dosage with nasopharynx cancer stadium classification using intensity-modulated radiotherapy technique
Authors
Mario Christian Sitompul, Zaenul Muhlisin, Indras Marhaendrajaya, Pandji Triadyaksa
Abstract
Nasopharyngeal cancer is caused by abnormal development of body cells
in the throat area. Radiotherapy is a standard therapy for treating
nasopharyngeal tumors or cancer using the Intensity Modulated Radiation Therapy
radiation technique. This study aims to determine the amount of radiation dose
patients receive at different stages of nasopharyngeal cancer. Analysis was
carried out on 25 nasopharyngeal cancer patients using the IMRT radiation technique
to obtain the relationship between the radiation dose received by Planning
Target Volume (PTV) and Organ at Risk (OAR). Patient dose data is obtained
through Dose Volume Histogram graph simulation using the Treatment Planning
System. Data analysis was carried out on PTV according to the International
Commission on Radiation Units and Measurements Report 62 of 1999 and ICRU
Report 83 of 2010, dose achievement at OAR with Quantitative Analysis of Normal
Tissue Effects in the Clinic (QUANTEC) guidelines and for stage classification
using the TNM system under the classification according to the American Joint
Committee on Cancer in 2018. The research analyzed the OAR in the patient's
brainstem, optic chiasm, spinal cord, parotid gland, oral cavity, and eye lens.
In general, PTV receives an average received radiation dose of 68.78 Gy. In
OARs, the highest radiation dose is found in the brainstem, followed by the
optic chiasm, spinal cord, oral cavity, parotid gland, and eye lens. The
results of the analysis showed that there was no significant difference between
radiation dose and Nasopharyngeal cancer stage classification. However,
analysis of individual patient doses showed that some patients received
radiation doses to the OAR exceeding the QUANTEC regimen.
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Pages:67-70
How to cite this article:
Mario Christian Sitompul, Zaenul Muhlisin, Indras Marhaendrajaya, Pandji Triadyaksa "Relationship analysis of radiation dosage with nasopharynx cancer stadium classification using intensity-modulated radiotherapy technique". International Journal of Multidisciplinary Research and Development, Vol 11, Issue 6, 2024, Pages 67-70
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