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VOL. 11, ISSUE 4 (2024)
Analysis of the effectiveness of ethanol extract of mangosteen peel (Garcinia Mangostana L.) in dealing with dyslipidemia: In vivo
Authors
Zeng Yi, Liena
Abstract
Dyslipidemia, characterized by elevated LDL cholesterol levels, poses a
significant risk for coronary heart disease and related cardiovascular
complications. However, the adverse effects associated with conventional
anti-dyslipidemia drugs have prompted the exploration of herbal alternatives,
such as mangosteen peel extract. This study aimed to evaluate the efficacy of
mangosteen peel extract in managing dyslipidemia, focusing on identifying
natural and safer treatment options. The experimental design employed a
pre-test and post-test group approach with a control, utilizing ethanol
extracts of mangosteen peels administered to male Wistar rats. Sample size
calculation based on the Federer formula dictated a minimum of 4 male Wistar
rats (Rattus norvegicus) per treatment group. The results demonstrated
significant improvements in lipid profiles, particularly in the highest dose
group, showcasing optimal reductions in total cholesterol, triglycerides, and
LDL levels, coupled with increased HDL levels observed in the Ethanol Extract
of Mangosteen Fruit Skin II and III groups. However, the Ethanol Extract of
Mangosteen Fruit Skin III group did not exhibit the same improvement as the
standard group. This study underscores the potential of Garcinia mangostana L.
peel extract in addressing dyslipidemia, highlighting its ability to reduce
total cholesterol, triglycerides, and LDL while enhancing HDL levels compared
to the control groups. The observed reductions in SGOT and SGPT levels also
indicate potential hepatoprotective effects. Further clinical studies in human
subjects are necessary to validate and ascertain its therapeutic efficacy.
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Pages:15-21
How to cite this article:
Zeng Yi, Liena "Analysis of the effectiveness of ethanol extract of mangosteen peel (Garcinia Mangostana L.) in dealing with dyslipidemia: <i>In vivo</i>". International Journal of Multidisciplinary Research and Development, Vol 11, Issue 4, 2024, Pages 15-21
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