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VOL. 11, ISSUE 2 (2024)
Application of zanthoxylum acanthopodium fruit extract in reducing dyslipidemia in male wistar rats undergoing high-fat diet and propylthiouracil (Ptu) treatment
Authors
Cui Dinghao
Abstract
Dyslipidemia is a lipid metabolism disorder caused by the interaction
of genetic and environmental factors, leading to the formation of atherogenic
lipids and an increased risk of premature cardiovascular disease. This study
aims to explore the effectiveness of antidyslipidemia from the extract of
Andaliman fruit. Using male Wistar rats as experimental animals in a study with
a Pre-test and Post-test group-only control design approach, phytochemical
screening results indicated that the methanol extract of Andaliman fruit
contains various phytochemical compounds, including Alkaloids, Saponins,
Flavonoids, Tannins, Steroids, and Terpenoids. This research concludes that the
methanol extract of Andaliman fruit significantly reduces total cholesterol,
triglycerides, and LDL levels while increasing HDL levels in experimental rats.
Additionally, the decrease in SGOT levels indicates a positive effect on liver
health and the potential to reduce the risk of Non-Alcoholic Fatty Liver
Disease (NAFLD). Although these findings are promising, further confirmation
through human studies is necessary before considering Andaliman fruit methanol
extract as an effective therapy or treatment. With observed improvements in
lipid profiles and liver health, the methanol extract of Andaliman fruit offers
potential as an active ingredient source for developing antidyslipidemia
therapy.
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Pages:92-98
How to cite this article:
Cui Dinghao "Application of zanthoxylum acanthopodium fruit extract in reducing dyslipidemia in male wistar rats undergoing high-fat diet and propylthiouracil (Ptu) treatment". International Journal of Multidisciplinary Research and Development, Vol 11, Issue 2, 2024, Pages 92-98
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