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VOL. 11, ISSUE 2 (2024)
Drug interaction between antibiotics and anti-cancer drugs against some pathogenic bacteria
Authors
Raed A Muhammad, Muhsin A Essa
Abstract

The current study was conducted with the aim of investigating drug interaction between antibiotics and some anti-cancer drugs (Adriamycin (Doxorubicin), 5-Fluorouracil, Paclitaxel, Carboplatin) and their effect on the sensitivity of both Staphylococcus aureus and Escherichia coli against these antibiotics.

The results that the studied bacteria showed multiple resistance to antibiotics. also the results showed that the studied bacteria were highly sensitive to the anti-cancer drug (5-FU), compared to other anti-cancer drugs. The results of the interaction test between antibiotics and the anti-cancer drugs added to them generally show that they were divided into a synergistic reaction, an antagonistic reaction, or no significant interaction, depending on the type of drug and the type of bacteria, and that the S. aureus were more sensitive than the E. coli to various drug interactions. The drug (5-FU) was the most efficient in its synergistic activity with antibiotics compared to the rest of the drugs, Some anti-cancer drugs interact with antibiotics and reduce their antibacterial activity. Based on this result it is necessary for oncologists to create a treatment plan and consider potential drug interactions between anti-cancer treatment and antibiotics in order to ensure the best treatment for patients.
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Pages:19-24
How to cite this article:
Raed A Muhammad, Muhsin A Essa "Drug interaction between antibiotics and anti-cancer drugs against some pathogenic bacteria". International Journal of Multidisciplinary Research and Development, Vol 11, Issue 2, 2024, Pages 19-24
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