Background: Menopause signifies the cessation of menstruation, with the premenopausal phase (typically between ages 40 and 45) characterized by hormonal fluctuations, including a decline in estrogen levels and an increase in follicle-stimulating hormone (FSH). This period is associated with various symptoms such as hot flushes, depression, and sleep disturbances. Additionally, deficiencies in vitamins and trace elements during this phase influence oxidative stress and electrolyte balance. Objective: To evaluate the levels and clinical significance of antioxidant vitamins (Vitamin C and Vitamin E) and electrolytes (Sodium and Potassium) in premenopausal women.

Methods: The study included 200 participants divided into two groups: 100 women with premenopausal symptoms (Group 1) and 100 age-matched women without symptoms (Group 2).

Results: The findings revealed a significant increase in serum sodium levels in premenopausal women, while potassium levels remained unchanged. Levels of antioxidant vitamins, specifically Vitamin C and Vitamin E, were significantly reduced (p < 0.0001) in the symptomatic group compared to controls.