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VOL. 11, ISSUE 12 (2024)
Reaction of Malonamide with schiff bases of benzal-4-Fluoroaniline and evaluation of products for their antifungal activity
Authors
Ravi Prakash, RB Singh
Abstract
Condensation of malonamide with
benzal-4-fluoroaniline and its C-phenyl derivatives (I-VIII) resulted in the
formation of solid compounds. The products have been identified as addition-
elimination products viz. benzalmalonamide and its derivatives (la-VIIIa)
respectively on the basis of elemental analysis, spectral studies and m.m.p.
determination (no depression) with an authentic sample. The results are at a
variance as compared to similar condensation of malonamide with benzalaniline.
The compounds la-VIIIa were tested in vitro for their antifungal
activity against Alternaria alternata, Fusarium oxysporum, Myrothecium
roridum, Helminthosporium gramineum and Colletotrichum capsici by spore
germination inhibition method. 3,4-Dimethoxybenzalmalonamide (Va) has been
found to be most effective compound of the present study.
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Pages:52-53
How to cite this article:
Ravi Prakash, RB Singh "Reaction of Malonamide with schiff bases of benzal-4-Fluoroaniline and evaluation of products for their antifungal activity". International Journal of Multidisciplinary Research and Development, Vol 11, Issue 12, 2024, Pages 52-53
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