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VOL. 11, ISSUE 1 (2024)
DNA cleavage efficiency of transition metal(II) schiff base complexes of 4-aminoantipyrine derivative by synthesis, characterization and antimicrobial study
Authors
Ravi Prakash, Raj Kumar, R B Singh
Abstract
A new bidentate Schiff base ligand derived from 4-aminoantipyrine and
O-acetoacetotoluidide and its CuII, CoII, NiII
and ZnII metal complexes have been synthesized and characterized by
microanalytical data, IR, UV-Vis, 'I NMR and mass spectra. The conductance
measurements indicate that all the complexes are electrolytes. The IR spectra
indicate the coordination of azomethine nitrogen atom of the Schiff base and
cyclic carbonyl group of the pyrazolone ring. The UV-Vis spectral data
demonstrate that the complexes have square-planar geometry. The FAB mass
spectra confirm the composition of the complexes of the type ML where M CuII,
CoII, NiII and ZnII. Their magnetic sus-
ceptibility values provide evidence for the monomeric nature. The gel
electrophoresis experiment has been carried out on the interaction of the
complexes with CT-DNA. The nuclease activity of the above metal complexes shows
that only the copper complex cleaves DNA in the presence of oxidant.
Antimicrobial activities of the compounds are tested in vitro against four bacteria and three fungi by the disc diffusion method.
The MIC value against the growth of micro-organisms is much larger for metal
chelates than the ligand.
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Pages:89-92
How to cite this article:
Ravi Prakash, Raj Kumar, R B Singh "DNA cleavage efficiency of transition metal(II) schiff base complexes of 4-aminoantipyrine derivative by synthesis, characterization and antimicrobial study". International Journal of Multidisciplinary Research and Development, Vol 11, Issue 1, 2024, Pages 89-92
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