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VOL. 10, ISSUE 9 (2023)
Analysis of the effectiveness of curcuma longa ethanol extract on isolated guinea pig tracheal smooth muscle in acetylcholine induction
Authors
Wang Junjie
Abstract
Asthma can be defined as a chronic inflammatory disorder that occurs in
the respiratory tract. Airway smooth muscle (ASM) contributes to COPD (Chronic
obstructive pulmonary disease). This study aims to analyze the effectiveness of
curcuma longa ethanol extract on isolated guinea pig tracheal smooth muscle in
acetylcholine induction. This research method is experimental to observe the
relationship of ethanol curcuma longa extract (EECL) to the effect of smooth
muscle relaxation using male guinea pigs weighing between 300-500 grams with
the age of 3-4 months. Experimental animals were divided into two groups, each
consisting of 4 animals. that curcuma longa ethanol extract has a relaxing
effect on tracheal smooth muscle isolated from experimental mice contracted
with acetylcholine. The ethanol extract of curcuma longa has the ability not
different from theophylline 2 x 10-4 M in reducing the contraction of the
isolated tracheal smooth muscle of cavia porsellus induced by acetylcholine,
the strength of acetylcholine without incubation contraction compared with
acetylcholine with EECL incubation showed statistically different results (p
< 0.05). The mechanism of the relaxing effect of curcuma longa on isolated
guinea pig smooth muscle is mediated through the inhibition of PDE enzymes.
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Pages:90-92
How to cite this article:
Wang Junjie "Analysis of the effectiveness of curcuma longa ethanol extract on isolated guinea pig tracheal smooth muscle in acetylcholine induction". International Journal of Multidisciplinary Research and Development, Vol 10, Issue 9, 2023, Pages 90-92
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