Hepatitis is the major cause of inflammatory condition of liver. It is commonly caused by both infectious (viral, bacterial, fungal and parasitic organism) and non-infectious (alcohol, drugs, auto immune disease and metabolic diseases). Hepatitis has many types, amongst all hepatitis B and hepatitis C are more prevalent pan world. HBV infection caused by hepatitis B virus which is responsible for different liver stages such as acute and chronic liver disease. It is water borne disease. HCV infection caused by hepatitis C virus, responsible for different stages of liver such as chronic liver disease, fibrosis, cirrhosis and liver carcinoma. Chemokines are a sub family of cytokines, acts as a chemo attractant for different cells, includes immune cells. CXCL10 is a small protein with 10 KD size binds with CXCL3 to mediate immune response by activating and recruiting leukocytes such as T cells, eosinophils, monocytes and NK cells. The aim of the review is to address recent finding regarding the relation between CXCL10 in both hepatitis B and hepatitis C.