The goal of this study was to compare the in vitro antibacterial and antioxidant activities of water- and methanol-prepared Momordica charantia leaf extracts. Initial phytochemical analysis identified several different bioactive chemicals, including glycosides, alkaloids, phytosterols, saponins, phenolic compounds, proteins, lipids and fixed oils, and flavonoids; these results were confirmed by thin layer chromatography. Antimicrobial activity was measured against Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, and Bacillus subtilis using the stokes disc diffusion and well diffusion methods. Methanolic plant extract showed the largest zone of inhibition against Escherichia coli using the disc method, whereas it was more efficient against Bacillus and Klebsiella using the well diffusion method. Antioxidant activity was determined by utilising both the DPPH and ABTS methods using ascorbic acid and gallic acid as standards. Furthermore, IC50 values were calculated.