Dental pain is one of the foremost reasons for patients seeking dental therapy. Some dental procedures can also lead to post-operative pain. The major part of periodontal therapy consists of relieving this pain safely and effectively to provide patient comfort. The most commonly prescribed agents for pain management include non-steroidal anti-inflammatory drugs. These are non-narcotic, non-opioid aspirin-like analgesics which do not produce physical dependence or abuse liability. However they have a wide range of effects on other organ systems which could have a negative influence. Hence it is of utmost importance to take into consideration these drug interactions before prescribing NSAIDs in daily practice.