Background: Low birth weight infants (LBWIs) are at an increased risk 20 times more likely to die than others, those infants are in more dangers to live normally. Nonnutritive Sucking Stimulation is recognized for enhancing successful feeding. Purpose: this study aimed to determine the effect of using Nonnutritive Sucking Stimulation on the incubation duration for LBWIs. Subjects and procedures: Sixty LBWI infants ranged in age from 30 to 36 gestational weeks of both sexes participated in this study. They were selected from the neonatal intensive care unit of Om El Masryeen and Abo el Reesh hospitals. They were assigned randomly into two groups of equal number representing study and control groups. Study Group in which infants received their medical treatment in addition to a selected physical theapy intervention aiming to improve their nutritive abilities during incubation period while infants in the control group subjected to medical treatment only. The physical therapy treatment program was conducted three times per day from date of admission until the infant reached grade 4-point ordinal scale in functional oral intake scale (FOIS). Results: There was a statistically significant increase in oromotor functional scale measures post treatment in the control and study groups compared with that of pretreatment with a statistically significant difference in post treatment values in favor to the study group (p > 0.05). Conclusions: Nonnutritive Sucking Stimulation is an effective modality that may be added to the treatment program used in low birth weight infants who have weak suckling.