In horticulture, pre-harvest fruit dropping is a very serious problem and is a major cause of annual yield losses in several horticultural crops. There are several biotic and abiotic factors that lie behind fruit dropping, like weather, temperature, heavy rains, lack of pollination, failure of fertilization, attack of insects and diseases, lack of nutrition and embryo degeneration, etc. Plant growth regulators are signalling molecules that are synthesised by plants and regulate different physiological, growth, and developmental processes in plants. Plant growth regulators play a very significant role in the prevention of pre-harvest fruit dropping in various horticultural crops. In the present review, we have discussed fruit drops, their causes, and the role of PGRs in prevention in different horticultural crops, including wax apple, citrus, litchi, gooseberry, etc.