International Journal of Multidisciplinary Research and Development

International Journal of Multidisciplinary Research and Development


International Journal of Multidisciplinary Research and Development
International Journal of Multidisciplinary Research and Development
Vol. 9, Issue 5 (2022)

Impact of selenium on aging and aging-related diseases-A review


Natarajan S Nimisha, Paul Virginia

Selenium (Se) is an essential dietary trace element that plays an important role in the prevention of inflammation, cardiovascular diseases, infections, and cancer. Selenoproteins contain selenocysteine in the active center and include, i.a., the enzymes thioredoxin reductases (TXNRD1–3), glutathione peroxidases (GPX1–4 and GPX6) and methionine sulfoxide reductase, involved in immune functions, metabolic homeostasis, and antioxidant defense.Ageing is an inevitable process, which, involves an imbalance between antioxidative defense and reactive oxygen species (ROS), changes in protein and mitochondrial renewal, telomere attrition, cellular senescence, epigenetic alterations, and stem cell exhaustion. These conditions are associated with mild to moderate inflammation, which always accompanies the process of ageing and age-related diseases. In the elderly, aging-related diseases include neuropsychiatric diseases, tumors, cardio-vascular diseases, and skin aging, among others. Selenium supplementation is an important strategy for anti-aging and the prevention of aging-related diseases and is of great significance for the elderly. However, with the accumulation of related research, selenium supplementation does not necessarily contribute to the prevention of aging and aging-related diseases. It is believed that a low level of selenium is beneficial to the human body. Thus, the effect of selenium on human aging and aging-related diseases is still controversial.
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How to cite this article:
Natarajan S Nimisha, Paul Virginia. Impact of selenium on aging and aging-related diseases-A review. International Journal of Multidisciplinary Research and Development, Volume 9, Issue 5, 2022, Pages 111-117
International Journal of Multidisciplinary Research and Development International Journal of Multidisciplinary Research and Development