International Journal of Multidisciplinary Research and Development

International Journal of Multidisciplinary Research and Development


International Journal of Multidisciplinary Research and Development
International Journal of Multidisciplinary Research and Development
Vol. 9, Issue 2 (2022)

Assessment of relationship between cardiac troponin-I and mortality in patients with severe COVID-19 infection


Mariam Aijaz Ahmad, Prakash Rao

Background and Objectives: the on-going COVID-19 pandemic is responsible for over 5 million deaths worldwide. The SARS-COV2 virus is now well known to affect respiratory, cardiovascular and neurological systems. Troponin I, traditionally used as a cardiac biomarker usually for the diagnosis of acute coronary syndrome (ACS). Troponin I levels were found to be raised in COVID patients requiring admission to the ICU. This study is aimed to evaluate the relationship between Troponin I and mortality in such patients and whether Troponin I levels can be used as a prognostic tool to determine severity in COVID patients. Materials and Methods: This study included patients diagnosed with COVID-19 via RTPCR from nasopharyngeal and pharyngeal samples, who were admitted to the ICU between May 2021 and August 2021. The Troponin I levels were measured for each patient at the time of admission and the patients were stratified into two groups (elevated vs. normal). Data was retrospectively reviewed and analysed. Results: The study included 257 COVID patients requiring admission to the ICU. Patients with elevated Troponin I levels were found to be older (77±13 vs. 58±16 years, p<0.0001). They were also more likely to be suffering from diabetes (p=0.0019), hypertension (p<0.0001), coronary artery disease (p<0.0001) and heart failure (p=0.0011). Patients with raised Troponin I levels at admission were more likely to have higher all-cause mortality (52% vs. 10%, p<0.0001). Conclusion: Elevation of Troponin I is commonly seen in patients with severe SARS-COV2 infection and is significantly associated with increased mortality.
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How to cite this article:
Mariam Aijaz Ahmad, Prakash Rao. Assessment of relationship between cardiac troponin-I and mortality in patients with severe COVID-19 infection. International Journal of Multidisciplinary Research and Development, Volume 9, Issue 2, 2022, Pages 35-40
International Journal of Multidisciplinary Research and Development International Journal of Multidisciplinary Research and Development