From ancient times the role of herbal medicine is significant. Several plants possess anti-cardiovascular activity. The important component is digitalis, reserpine, aspirin effective for chest pain. Natural plant treatment is used against arrhythmia, venous insufficiency, cerebral insufficiency, atherosclerosis, angina pectoris, hypertension, CHF. At home, people used different remedies to overcome the chances of chest pain. So, the new research indicates that many natural plant derivative formulations available in the market can be used against heart failure and other illnesses.