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VOL. 8, ISSUE 9 (2021)
Bone formation ability of the wood of Taxus yunnanensis in pioglitazone treated diabetic rats
Authors
Kumar Venkatesan, Rama Ramaiah, Krishnaraju Venkatesan, Premalatha Paulsamy, Kalpana Krishnaraju
Abstract
Using streptozotocin (STZ)-induced diabetic rats co-treated with pioglitazone, Methanolic (MeOH) extracts of Taxus yunnanensis (TYE) wood were studied for their impact on bone loss. Pioglitazone (PGZ) has been shown in animal experiments to inhibit bone growth and promote bone resorption. Control (vehicle treatment), Streptozotocin (diabetes), Taxus yunnanensis extract (TYE), Pioglitazone (PGZ), and PGZ +TYE were the five groups of six Wistar albino rats investigated. Each drug was administered through gastric gavage for a total of 35 days. In rats, the effects of TYE on blood glucose, HBA1C, and bone mineral density were investigated. Normal control rats were given saline to drink (NC). Blood glucose levels, HBA1C levels, and bone mineral density all improved after TYE therapy. These findings show that TYE might be beneficial in the treatment of anti-diabetic drug induced bone loss.
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Pages:124-126
How to cite this article:
Kumar Venkatesan, Rama Ramaiah, Krishnaraju Venkatesan, Premalatha Paulsamy, Kalpana Krishnaraju "Bone formation ability of the wood of <em>Taxus yunnanensis </em>in pioglitazone treated diabetic rats ". International Journal of Multidisciplinary Research and Development, Vol 8, Issue 9, 2021, Pages 124-126
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