Background: Due to various lifestyle modifications and other causes, metabolic disorders are on the rise in developing countries such as India. Patients with Type 2 DM often experience diabetic nephropathy, they can also develop other renal diseases, pathologically unrelated to diabetes and known as non-diabetic kidney disease (NDKD) which may present as isolated lesion or superimposed with diabetic nephropathy. The spectrum of NDKD type-2 diabetics is primary glomerular disease, secondary glomerular diseases and tubulointerstitial disease. Hence, the need was felt to carry out this study to evaluate the renal biopsies performed on type-2 diabetic patients with suspicion of NDKD and to associate the histopathological findings with clinical presentations and laboratory parameters. Methods: A prospective study was conducted at SDM Medical College and Hospital, Dharwad among 50 patients with type 2 DM. Data was collected using a predesigned, pre-tested, semi- structured questionnaire and analysed using SPSS software version 16. Results: Out of 50 study subjects, 32% had Non- diabetic renal disease (NDRD), 28% had NDRD superimposed on underlying DN and 40% had Diabetic nephropathy (DN). Histopathological diagnosis among the total 30 patients with NDRD and NDRD+DN showed ATIN in 23.3%, Benign nephrosclerosis in 10%, Membranous nephropathy in 10%, Membranoproliferative glomerulonephritis in 10%, IgA nephropathy in 10%, Postinfectious glomerulonephritis in 10%, Lupus nephritis in 10%, Acute pyelonephritis in 6.7%, Mesangioproliferative glomerulonephritis in 3.3%, Focal segmental glomerulosclerosis in 3.3% and Crescentic glomerulonephritis in 3.3% of the patients. Conclusion: The incidence of NDRD among DM patients was very high. Shorter duration of DM with haematuria, proteinuria, absence of retinopathy, with low serum complement levels strongly predict NDRD. Renal biopsy should be considered in NDRD patients to determine the underlying cause of proteinuria.