Clinical epidemiology and advancement in diagnostics of SARS-CoV-2 infection
Vikram Singh, Girija Kumari
Severe acute coronavirus 2 (SARS-CoV-2) respiratory syndrome has spread to almost every part of the globe, causing social unrest. Coronavirus 2019 (COVID-19) causes fever, sore throat, cough, muscle pain, dyspnea, confusion and headache. This can lead to life-threatening breathing failure and can also damage the heart, lung, liver and nervous systems. SARS-CoV-2 infections are also misleadingly diagnosed with influenza infection, and bacterial seasonal high-breath infections. For the interpretation of epidemiology, contract-tracing, case control and for the repression of SARS-CoV-2 diagnostic assessments for COVID-19. Diagnostic testing in terms of disease and outbreak control, laboratory diagnosis of SARS-CoV-2 is highly significant. The development of rapid treatment tests with greater sensitivity and specificity is the key diagnostics as this helps prevent SARS-CoV-2 infection from spreading. Early diagnosis of viral infections is a strong improvement for the application of particular interventions in public health such as outbreak prevention, and closing of high-risk specific areas. At present, the gold standard procedure for routine diagnosis for COVID-19 infection is a Nucleic Acid Amplification Test (NAAT)-based RT-PCR technique. There have been many other advances such as bio-sensor and nanomaterial bases diagnostics. The creation of genome archives and open access genomic libraries for global researchers is simple for managing the outbreak of COVID-19 and speeding up the diagnosis and drug processes. This study summarizes numerous molecular diagnostic approaches, techniques and innovative research strategy, and clarifies the rapidly increasing range of diagnostic tests available and in-depth, including nanomaterial-based instruments to be used by health practitioners as resources guidance.
Vikram Singh, Girija Kumari. Clinical epidemiology and advancement in diagnostics of SARS-CoV-2 infection. International Journal of Multidisciplinary Research and Development, Volume 8, Issue 4, 2021, Pages 144-149