International Journal of Multidisciplinary Research and Development

International Journal of Multidisciplinary Research and Development


International Journal of Multidisciplinary Research and Development
International Journal of Multidisciplinary Research and Development
Vol. 8, Issue 3 (2021)

Prevalence of diastolic dysfunction with normal systolic function in asymptomatic type 2 DM


Pavitra KM, C Ramachandra Bhat, Gireesh

Background: In the last thirty years, diabetic heart diseases have increased at a significant rate. It is being considered as a clinical anomaly by different researchers and experts on the topic. According to various studies even if there is no indication of coronary artery disease and hypertension, then as well, there are high chances of heart failure in diabetic patients. People with diabetes mellitus (DM) tend to have high pre-clinical diastolic dysfunction. Aim: Aim of the current study was to evaluate the relationship between diastolic dysfunction and Type 2 DM. In this research, the asymptomatic subjects was considered. To achieve the aim of the study, we assessed the occurrences of diastolic dysfunction along with normal systolic functions in asymptomatic Type 2 DM. The study also evaluated its relationship with duration of DM, age, obesity, Glycosylated haemoglobin (HbA1c) and microangiopathies. Materials and Methods: Thirty normotensive people with Type 2 DM for more than 3 years were selected for the current study, but it did not involve people with cardiac diseases. Further, a sample of 30 healthy subjects as the control group was also selected for this study. The researcher was carried out for over one year at KVG Medical College and Hospital Sullia (D.K) Karnataka from March 2019 to February 2020. Results: During the study, it was observed that the mean for waist circumference (WC) was computed to be much higher for the case group in comparison to participants from the control group. The mean for waist to hip ratio (WHR) was also higher for case group than that of the control group. Similarly, mean for total serum cholesterol (TC) and serum triglyceride levels (TG) was higher in the case group as opposed to the control group. Low density lipoprotein (LDL) cholesterol’s mean was also higher, while the mean for High-density lipoprotein (HDL) cholesterol was found to be lower in the case group than in the control group. Mean of blood sugar level (BSL) for the case group was much higher while the mean for E/A {early diastolic rapid filling (E-wave) and atrial contraction late filling (A-wave) velocities} was computed to be very low as compared to the control group. E/e’s {mitral peak velocity of early filling (E) to early diastolic mitral annular velocity (e)} ratio’s and diastolic dysfunction’s mean for the case group was higher in comparison to the control group. During the study, diastolic dysfunction was found to be more prevalent in the participants than HbA1c > 7.5% and HbA1c < 7.5%. Serum HDL’s correlation was positive with E/A ratio and negative correlation with E/e’ ratio. A statistically significant association was observed during the regression analysis between diastolic dysfunction and factors of WC, WHR, serum TG level, HbA1c, DM, autonomic neuropathy and retinopathy. Conclusion: It can be concluded that the prevalence of diastolic dysfunction is statistically significant and high in people with asymptomatic Type 2 DM in comparison to the control group. Duration of diabetes, advanced ageing, high obesity, retinopathy, postural hypotension, dyslipidemia and HbA1c are associated with LV diastolic abnormalities.
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How to cite this article:
Pavitra KM, C Ramachandra Bhat, Gireesh. Prevalence of diastolic dysfunction with normal systolic function in asymptomatic type 2 DM. International Journal of Multidisciplinary Research and Development, Volume 8, Issue 3, 2021, Pages 79-81
International Journal of Multidisciplinary Research and Development International Journal of Multidisciplinary Research and Development