This research was conducted to evaluate the effect of two agrochemicals, atrazine and cyhalothrin on the progesterone level and reproductive performance of pregnant rabbits expose by inhalation or oral administration and the dietary digestibility of growing rabbits. The two chemicals are extensively used in agriculture for the protection of agricultural produce. Atrazine and cyhalothrin are linked with reproductive irregularities in animals and humans. Atrazine and cyhalothrin affect the normal function of the endocrine system which may lead to a negative reproductive system. Past research predominantly focuses on the disrupting of the estrogen and/or androgen receptor, but the hormonal function of animals may be disrupted in many different ways based on exposure. In this research, our focus was on the serum progesterone level of pregnant rabbits. The chemicals target the neuroendocrine framework made up of organs in the body that works together with the central nervous system to control and regulate reproductive functions. The most prominent of these is the hypothalamic-pituitary-gonadal (HPG) axis which is important to perpetuate appropriate reproductive function. When these get disrupted, it decreases the normal rate of progesterone secretion and functions. Twelve New Zealand White rabbits between the age range of 10 to 11 months old and weighing ± 1.87 kg were used for the evaluation. Ten females and two males, the study was conducted using a Pretest- Posttest Experimental Design with one treatment group (5 females and one male for mating) and one control group (5 females and one male for mating). Five female rabbits at gestation day 14 were exposed to atrazine and cyhalothrin by inhalation at a different time for seven days at a dose and rate equivalent to that recommended for a maize field. The results showed a significant reduction in the serum progesterone of the exposed animals, thus resulting into series of reproductive disorders like spontaneous abortion, premature birth, birth abnormality, low daily weight gain, and loss of appetite in doe, and low dietary digestibility of growing rabbits (P<0.05). In the second phase of the experiment, five female rabbits at gestation day 14 were exposed to atrazine and cyhalothrin in their drinking water at a different time at a dose of 0.003 mg/L respectively. The results showed a significant effect of atrazine on the progesterone level (P<0.05). At the dose of 0.003 mg/L, cyhalothrin did not affect the progesterone level of the exposed rabbits, but when the dose was increased to 0.005 mg/L, seventy-five percent abortions were recorded.