Psoriasis is an autoimmune disorder. It is characterized by chronic inflammatory condition of skin. It leads to thick, scaly plaques on skin. Current medication involves symptomatic treatment by the various moisturizers; however, the effects do not last long and recurrence occurs. Based on several ancient text a combination of herbs was formulated and named as Skimune tablet and Gel. The beneficial effects of Skimune Tablet and Gel were clinically evaluated on patients with mild to moderate psoriasis. The Dermatology Life Quality Index (DLQI) and Psoriasis area & severity index (PASI) score was evaluated to understand the effects of tablet and Gel. Skimune tablet was found to be well tolerated in patients. skimune Tablet and Gel showed significant improvement (P <0.05) before and after treatment with patient with psoriasis.