Wild plants in arid Rangelands are of great importance as not only a source of livestock forage and land covers but also uses for ethnobotanical and pharmaceutical uses. The present study was conducted for evaluating different parts of wild Ziziphus nummularia nutritive and various medicinal attributes. Antimicrobial and antibacterial activities were also studied. Fruits and leaves were collected from Cholistan desert. Results revealed that the antioxidants like Flavonoids, alkaloid, and phenolic contents were found both in fruits and leaves. Fruits of the plant showed higher phytochemicals concentration and nutrient concentrations as compared to leaves. Leaves showed more ash and carbohydrate contents, and better antimicrobial activities were observed in the mixture of different solvents extracts of leaves against gram positive and gram negative bacterial strains (Bascilus subtillis and Pseudomonas aeruginosa). Antifungal activities were also observed in fungus species (Aspergillus niger, Fusarium oxysporum and Penicillium glabrum) and found statistically significant.