The spatial analysis of prevalence of disease focus on the disease prone areas. The Hyderabad city is the one of Metros in the India, which is evident of highest number of Pandemic Corona Virus Disease 2019 (COVID-19) cases. Spatial analysis of COVID-19 gives the understanding of pattern of disease spread in Hyderabad. Most of the cases in Telangana State are reported from Grater Hyderabad only. In this paper an attempt is made to study the spatial distribution pattern of Pandemic COVID-19 in Greater Hyderabad, in the months of April 2020 and July 2020. The spatial distribution is presented using GIS (Geographical Information System).The study revealed that, in the south-eastern part of the city, Hayath Nagar circle in L.B Nagar zone is not being recorded any COVID-19 cases.