Antibiotic resistance patterns and frequency of ESBL producing isolates of
Fazila Nargis, Sukhvinder Kaur, Arif Ali, Qazi Mohd Rizwannul Haq
Extended spectrum β - lactamase (ESBL) producing strains of E. coli have caused paramount therapeutic problems globally as majority of them are resistant to variety of antibiotics. In this study, the antibiotic susceptibility testing was carried out to assess the resistance patterns offered by the 70 E. coli isolates to seven different antibiotics and to conduct phenotypic screening for ESBL producing E. coli strains cultured from the hospital sewage water of South East Delhi during 2017-2018. The Phenotypic screening for ESBL production using preliminary and PDCT revealed 35 (50%) out of 70 E. coli isolates as ESBL producers and remaining samples were considered as non-ESBL producers. Further, the presence of genes responsible for ESBL in E. coli was confirmed by PCR based techniques. Based on our results, it is recommended that prescription of oxyimino-cephalosporins should be restricted to susceptible isolates and that the use of other effective antibiotics must be considered. There is also a necessity of constant and regular antimicrobial sensitivity surveillance for the presence of ESBL genes. Preliminary disinfection of the hospital sewage before it exits the premises will assist in minimizing the spread of antibiotic resistant bacteria to the environment.
Fazila Nargis, Sukhvinder Kaur, Arif Ali, Qazi Mohd Rizwannul Haq. Antibiotic resistance patterns and frequency of ESBL producing isolates of. International Journal of Multidisciplinary Research and Development, Volume 7, Issue 1, 2020, Pages 161-165