This study was intended to to investgate the influence of modular based curriculum on students understanding level in Wolaiata Sodo University, College of Natural and Computatinal Science. The key purpose of the is to find out the effectiveness of modular approach in teaching order of assessing the student learning, performance and achievement; and to determine whether the modular teaching is more effective than traditional methods. The study was experimental type and survey type. The sample for this study was drawn from the students of College of Natural and Computational Science. Sample size was consisted of 130 students. The data were collected from both groups (controlled and experimental). The survey data were collected using self-administered questionnaire. Questionare included some socio-demographic, Economic, students’ academic variables. Data were cleared and and analsed using SPSS version 16.0. Ordinal Logistic regression was employed in methods of data analysis. The variables which has correlates with understanding level of students were identified using the ordinal logistic regression analysis. The results revealed that students’ scores were in the favor of usage of modular teaching approach. So, it is recommended that the modular approach should be widely used at university levels of education in Wolaiata Sodo University, Natural and Computational Science College, in partical and in Ethiopian University in general. And it is also recommended that scientific measurments should be taken for variables which makes significant varation on students understanding level. It is also believed that this study can be used as a base line information for further study of the problems on large scale of regional or national level.