Objective:Present study was designed to compare the outcome results of endonasal endoscopic dacryocystrhinostomy (DCR) with or without Mitomycin C (MMC) application. Methods: 80 patients with nasolacrimal duct obstruction. They were divided into two equal groups according to the planned surgical intervention technique. Group A: Included 40 patients with nasolacrimal duct (NLD) obstruction who underwent endonasal endoscopic DCR with (MMC) application. Group B: Included 40 patients with NLD obstruction who underwent endonasal endoscopic DCR without (MMC) application. All cases underwent full history taking, clinical examination, laboratory investigations; surgical intervention and follow up for 6 months postoperatively. Results: In the present study, group(A) DCR with MMC application it was found that the success rate was reported in 37 cases (92.5%) and failure in 3 cases (7.5%); while in group (B) DCR without MMC application it was found that the success rate was reported in 33 cases (82.5%) and failure in 7 cases (17%). Conclusion: Results of the present study revealed that, endoscopic DCR with MMC application had a comparable success rate over endoscopic dacryocystrhinostomy (DCR) without MMC application and had advantages of having a higher success rate, less intraoperative and postoperative complication.