Ameliorative activity of ethanolic leaf extracts of carica papaya and newbouldia laevis on kidney of alloxan-induced diabetic rats
Ifegwu NO, Anibeze CIP
Objective:This study was carried out to investigate the effect of the ethanolic leaf extracts of Carica papaya (C. papaya) and Newbouldia laevis (N. laevis) on the histology of the kidney of alloxan-induced rats. Methodology: Forty male Wistar rats weighing between 160g – 200g were randomly assigned to eight Groups A - H of 5 rats each. Group A served as the control group and was not induced with diabetes, while Groups B – H were induced. Groups A and B received distilled water only, while Groups C - H received 200mg/kg of C. papaya, 400mg/kg of C. papaya, 200mg/kg of N. laevis, 400mg/kg of N. laevis, 200mg/kg of C. papaya + 200mg/kg of N. laevis and 400mg/kg of C. papaya + 400mg/kg of N. laevis respectively for 28 days. On day 29 of the experiment, the animals were sacrificed and kidney of each rat was harvested for histological study. Results: There were severely damaged renal tissue with severe tubular necrosis, glomerular atrophy and coagulative necrosis of glomeruli which leads to the closure of the malpighian layer of the animals in group B when compared with the control group. These effects were ameliorated in Groups C - H which received the variable doses of the ethanolic leaf extracts with more positive effects on the groups that received the combined ethanolic leaf extracts. Conclusion: The leaf extracts of C. papaya and N. laevis have ameliorative effect on the histology of kidney of alloxan-induced rats.
Ifegwu NO, Anibeze CIP. Ameliorative activity of ethanolic leaf extracts of carica papaya and newbouldia laevis on kidney of alloxan-induced diabetic rats. International Journal of Multidisciplinary Research and Development, Volume 6, Issue 7, 2019, Pages 17-21