For centuries, plants have been used in traditional medicines and there has been recent interest in the chemo preventive properties of compounds derived from plants. In the present study, five samples of plants Psidium guajava, Schoenanthus cymbopogone, Solenostemma argel, Hyphaene thebaica and Petroselinum crispum are common plants widely used in many parts of Sudan for medicinal purposes or herbal medicine to treat various diseases, The collected plants were subjected to sequential extraction using petroleum ether, ethyl acetate, acetone and ethanol as solvents. The results clearly indicated variation of the total yields, the P. guajava extract gave the highest yield (7.001%) followed by S. argel (6.551%), P. Crispum (4.760%), S. Cymbopogone (4.633%) and H. thebaica (2.538%.The extract of plant samples were evaluated by employing in vitro anti-oxidant using 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging and 2,2´-Azinobis 3-ethylbenzothiazoline-6-sulfonic acid(ABTS) free radical scavenging. Each sample under assay condition showed free radical scavenging effect of DPPH and ABTS. Petroleum ether extract for plant samples revealed a non-significant free radical scavenging activity with DPPH reagent while the highest scavenging ability was exhibited by ethanol extract (90%) that may be due to polarity of ethanol. Most extracts with ABTS reagent exhibited good antioxidant activities (69% – 94%) compared to DPPH, The highest scavenging ability was exhibited by ethanol extract from P. guajava (94%), while the lowest was determined in the acetone extract of P. crispum (69%). Among plant extracts, the P. guajava showed stronger IC₅₀ values (0.477) than other plant extracts.