Hepatoprotective potential of ethanolic leaf extracts of Carica papaya and Newbouldia laevis on alloxan-induced diabetic wistar rats
Ifegwu NO, Anibeze CIP, Ndukwe GU, Njoku-Oji NN, Agbai JU, Opara JK, Asebioyo SK
Objective:This study was carried out to investigate the effect of the ethanolic leaf extracts of C. papaya and N. laevis on the liver enzymes of alloxan-induced Wistar rats. Methodology: Forty male Wistar rats weighing between 160g – 200g were randomly assigned to eight Groups A - H of 5 rats each. Group A served as the control group and was not induced with diabetes, while Groups B – H were induced. Groups A and B received distilled water only, while Groups C - H received 200mg/kg of C. papaya, 400mg/kg of C. papaya, 200mg/kg of N. laevis, 400mg/kg of N. laevis, 200mg/kg of C. papaya + 200mg/kg of N. laevis and 400mg/kg of C. papaya + 400mg/kg of N. laevis respectively for 28 days. On day 29 of the experiment, the animals were weighed and sacrificed; and blood samples were collected from each of the animals for serum analysis. Results: There were significant (P?0.05) decrease in body weight and significant (P?0.05) increase in serum levels of ALT, AST and ALP of the animals in group B when compared with the control group. These effects were ameliorated in Groups C - H which received the variable doses of the ethanolic leaf extracts with more positive effects on the Groups that received the combined ethanolic leaf extracts. Conclusion: The leaf extracts of C. papaya and N. laevis have ameliorative effects on the body weight and serum levels of ALT, AST, and ALP of alloxan-induced Wistar rats.