Nasal Polyps represent a challenging diagnosis for the physician to treat. Management of nasal polyps forms a large part of the workload because the available treatment modalities having unsuccessful results with reincarnation of removed polypoidal tissues. Among the Ayurvedic treatments, fumigation treatment (Doopana Kalpana) was used for the management of Nasal polyposis. This study aimed to introduce a new treatment modality with new formulation, which named as Rakta Apamargadi dhooma varti. It had been practiced clinically but not scientifically evaluated. In the clinical study 20 patients were selected between the age of 16-60 years irrespective of their sex, religion, occupation & habitat etc. They were divided randomly by lottery method into two groups. Group A was treated with Rakta Apamargadi dhooma varti as local treatment with internal medicine and Group B was treated only with internal medicine. All the patients were completed the treatment and follow up study. According to analysis, fumigation treatment has been shown better result for nasal obstruction and reducing the size of the polypoidal sprouts. However, while considering the other symptoms, headache, running nose, sneezing and Itching of eyes, both groups have been shown significant results.