Despite the fast-paced invention of Information and Communication Technology (ICT) devices, modified to meet health needs of consumers of healthcare, and coupled with the growing awareness about the availability and benefits of these e-health applications to human health improvement, promotion, protection, rehabilitation, and prevention and treatment of diseases and disabilities, there is a large body of evidence of resistance to the use of e-health in healthcare services delivery by consumers and providers of healthcare in developing countries. This paper therefore intends to discuss the barriers that have led to this resistance, and proffer solutions.