The paper examines the current situation of application of knowledge management software at E&Y and Unilever in Vietnam, comparative analysis of application of knowledge management software at E&Y and Unilever in Vietnam, making recommendations solutions to improve the application of knowledge management software in Vietnamese enterprises to find out the reality of application of knowledge management software at E&Y and Unilever in Vietnam has brought remarkable success in knowledge management in enterprises, knowledge management software in E&Y and Unilever companies have their own characteristics, different in purpose, success and time, measures to improve the application Using knowledge management software needs to be invested in a special way in the professional work associated with the development n of knowledge economy.