Research focusing on the implementation of manufacturing flexibility and its implication on the operational performance of manufacturing SMEs is limited. This study is aimed to find out the implementation of five different types of manufacturing flexibility and it’s on four different aspects of operational performance. In particular, this study was intended to examine if the degree of manufacturing flexibility and operational performance differ across company size, age, age, market orientation, and sector. This study followed a survey method to collect data concerning the implementation of manufacturing flexibility and its implication on the operational performance of manufacturing SMEs. The sample involved in this study comprises 174 Indonesian manufacturing SMEs located in Cikarang Region, West Java Province of Indonesia.The results revealed that manufacturing flexibility and operational performance vary across company size, age, and market orientation, however, there were only two types of manufacturing flexibility scores that follow this pattern. Furthermore, the results demonstrated that company size significantly does not affect scores of manufacturing cost performance, indicating that company size had little impact on manufacturing cost performance. Lastly, it was found that scores of product quality performance significantly vary across ages and market orientation. A similar pattern takes place in scores of manufacturing lead time and delivery performance.