Androgen suppression therapy (AST) serves an important role in the treatment of patients with prostate cancer. However, AST leads a number of well-established toxicity-related musculoskeletal deficits (e.g., skeletal muscle loss, and strength), osteoporosis and skeletal fractures that can substantially reduce quality of life, physical function, and independence. Physical exercise has been suggested as a key lifestyle intervention due to its potential to limit and even reverse such toxicities. Purpose: The purpose of the study was to determine which is more effective in improving quality oflife in prostate cancer patients undergoing androgen suppression therapy: Resistive or Aerobic exercises? Subjects and Methods: Thirty patients who had prostate cancer undergoing AST were randomly divided into 2 equal groups each one has 15 patients. Group A included 15 patients who received resistive exercise for two months/ 3times per week, Group B included 15 patients who received low volume aerobic exercise for two months/ 3times per week. Short Form 36-Item Health Survey (SF-36) was used to measure quality of life in both groups. Results: The results of this study showed significant increase in several aspects of quality of life in group A that used resistive exercises over group B that used aerobic exercise including (PF, P= 0.001; RP, P= 0.01; GH, P= 0.02; VT, P= 0.004; SF, P=0.002; MH, P= 0.01). Conclusion: It was concluded that resistive exercises had a greater value and more significant effect compared with aerobic exercises in improving QOL in patients with prostate cancer undergoing androgen suppression therapy evaluated by Short Form 36-Item Health Survey (SF-36) and therefore reverses its related side effects.