Purpose: To assess the severity of the liver cirrhosis by measuring the level of insulin like growth factor 1 in the serum of the upper Egypt patients and controls.

Design: Cross section design.

Methods: One hundred patients with liver cirrhosis selected from out patients clinic of internal medicine department, Al-Azhar Assuit University hospital, twenty healthy individuals were being selected as a control group.

Results: Reported 24 months Study Of Insulin like Growth Factor1 as a marker of severity of liver cirrhosis in upper Egypt patients there is IGF 1 was significantly lower in child class C than child class B; also IGF 1 was significantly lower in child class B than class A.

Conclusion: IGF-1 can be used as an index for evaluating the severity of cirrhosis.