Cervical spondylosis is a chronic degenerative process that affects the vertebral bodies and intervertebral disc of the neck. The objective was to find out the effectiveness of Myofascial release technique and Maitland’s mobilization in cervical spondylosis patients and to compare it in terms of pain, functional ability and range of motion. Total 30 participant were involved. Group A were given MFR, and group B were given Maitland mobilization for three weeks and pain, functional ability and range of motion were assessed pre and post intervention. Data analysis was done using paired and unpaired ‘t’ test. Result showed statistically significant improvement in the Group A as compared to Group B. Conclusion was that Myofascial release is more effective than Maitland mobilization in cervical spondylosis patients in improving pain threshold, functional ability and range of motion.