Objective: To assess the therapeutic efficacy of aerobic exercises on nitric oxide after renal transplantation. Material and Methods: Thirteen patients (male or female) who had decreased in renal function (dysfunction of nitric oxide) and were selected randomly from any Hospitals in Cairo, and these patients were randomly subdivided into two equal groups; (15 patients for each): Group (A) (Study group): The study group includes 15 patients who had decreased in renal function (dysfunction of nitric oxide) and their ages were ranged from 30 to 45 years. That group was received aerobic exercises in addition to their routine of medications. Group (B) (Control group): The study group includes 15 patients who had decreased in renal function (dysfunction of nitric oxide) and their ages were ranged from 30 to 45 years. That group was received medications only.All patients All patients were suffered from renal complication (decreased NO). Exclusive criteria were subjects who had other co morbidities which affect results. Results:when comparing the two groups (A and B) before treatment, the mean ± SD values were 27.05 ± 3.91 and 28.49 ± 4.88 respectively which indicated no significant difference (p= 0.382), while comparing the two groups after six weeks of treatment, the mean ± SD values were 38.82 ± 3.66 and 34.98 ± 4.75 respectively which indicated a significant difference (p= 0.02) in favor of group A (MD= 3.84) and % of improvement was 9.89 %. Conclusion: It was concluded that Aerobic exercises had significant effect on nitric oxide after renal transplantation.