Fluoride is an environmental pollutant present in dissolved state largely in many sources of drinking water affecting many organs in human being when ingested in high levels for prolonged period. Effects of sodium fluoride in liver cytoarchitecture of albino-rabbit was studied in the present experimental work as well as its effect on gross body structure. Six adult healthy albino-rabbits were divided into 3 groups (2 rabbits per each group). The first group served as control group and received de-ionized water. The second group was treated with 0. 5% of sodium fluoride solution and third group was treated with 3% of sodium fluoride solution for 4 months. At the end of the experiment, the animals were sacrificed by ether anaesthesia and livers were dissected out and processed for histopathological study. The present experimental work showed that exposure to sodium fluoride for 4 months in high doses resulted in degenerative changes in liver cytoarchitecture and also loss of body weight and skin rashes all over the body.