International Journal of Multidisciplinary Research and Development

International Journal of Multidisciplinary Research and Development


International Journal of Multidisciplinary Research and Development
International Journal of Multidisciplinary Research and Development
Vol. 4, Issue 9 (2017)

Randomized controlled trial to evaluate the efficacy of lycopene in combination with vitamin E and selenium in the treatment of leukoplakia


Dr. Anjani Kumar Shukla, Dr. Ravi Kumar, Dr. Ashok Kumar

Aims and Objectives: A randomized controlled study was carried out to evaluate the efficacy of lycopene in combination with vitamin E and selenium in the treatment of leukoplakia in patients visiting dental college Jharkhand. Materials and Methods: Forty patients of leukoplakia were randomly categorized (irrespective of size and severity of the lesions) in two groups: Group A and B. Group A consisting of 20 patients were administered combination of lycopene (3 mg), vitamin E (200 I.U.) and selenium (100 mcg) twice daily and group B consisting of 20 patients were given placebo capsules once daily for a period of 4 months. Post-treatment follow-up period was 3-4 months. The product used in the study was LYC-O-MATO soft gels, manufactured by Mano pharmaceuticals, Chennai, India. The treatment outcome was evaluated both clinically and histologically and the results were statistically evaluated using Student’s unpaired ‘t’ test. Results: The results showed that the patients receiving lycopene in combination with vitamin E and selenium have statistically significant improvements both clinically and histologically as compared to those receiving placebo and with no side effects. Conclusion: The study results proved that the efficacy and safety of lycopene along with selenium and vitamin E in the management of oral leukoplakia.
Download  |  Pages : 44-46
How to cite this article:
Dr. Anjani Kumar Shukla, Dr. Ravi Kumar, Dr. Ashok Kumar. Randomized controlled trial to evaluate the efficacy of lycopene in combination with vitamin E and selenium in the treatment of leukoplakia. International Journal of Multidisciplinary Research and Development, Volume 4, Issue 9, 2017, Pages 44-46
International Journal of Multidisciplinary Research and Development International Journal of Multidisciplinary Research and Development