The revival of interest in natural drugs especially those derived from plants, stands in the last decades mainly because of widespread belief that “green medicines” are healthier and safer than the synthetic ones. The use of herbal medicine reflects the long history of human interaction with environment. The Himalaya region is rich in diverse traditional knowledge system due to the culture and environmental diversity. The description of Himalaya medicinal plants can be seen in ancient as well as modern literature including those Ayurveda, Yunani and Western systems of medicine nearly 20,000 species of plants, highlight 75 major species of medicinal flora out of which at least 25 were most sought after of during the last decade.