Introduction: Knowledge and attitude is persistent dimension to get either positively or negatively towards a person or a profession. Various studies revealed that high school students scored a reasonable level on the knowledge dimension but didn’t achieve high score on the attitude dimension. If the students possess a adequate knowledge and favorable attitude towards nursing, then the students would be attracted towards nursing profession. Aim: An exploratory study was undertaken to assess the knowledge and attitude regarding nursing as a career among adolescents in selected junior colleges of Pune city. Material & methods: The data was collected from 200 adolescents who were selected by non-probability purposive sampling technique. A valid and reliable structured knowledge questionnaire and attitude scale was used to collect the data. The data collection technique was questioning (paper and pencil). Results: The finding of the study shows that the adolescence possesses average knowledge regarding nursing as a career and they don’t possess a favorable attitude towards nursing. The co-efficient of the co-relation between knowledge and attitude score was 0.35 indicating a moderate co-relation at 0.05 level of significance.