Background: The introduction of synthetic prosthesis for open inguinal hernia repair has reduced the rate of recurrence, allowing research to focus on safeguard against postoperative pain. In an attempt to decrease chronic pain, a partially absorbable, light weight and self-gripping mesh was invented. This study evaluated short-term outcomes of Lichtenstein technique of hernia repair using Parietex ProGrip monofilament polyester mesh in Egyptian patients with inguinal hernias. Patients and Methods: Prospective analysis of 50 patients underwent Lichtenstein technique for hernia repair using the Parietex ProGrip mesh between October 2013 and April 2016 at Al-Azhar university hospital, Assiut, Egypt. The primary outcome was chronic pain measured at 3 weeks, 3, 6, and 12 months postoperatively. Secondary outcomes were perioperative and early postoperative complications, return to usual activities and recurrence rate of the hernia. A difference in pain between preoperative and postoperative values was calculated at all follow-up time points. Results: Fifty cases (all males) were studied. Mean ± standard deviation (SD) patient age was 39.2 ± 10.4 (range 18–60) years. Most hernias were Gilbert's type II [12 (24%)] or III [16 (32%)]. During 12 months postoperatively, none of the patients developed systemic postoperative complications or recurrent hernia. The mean ± SD pain visual analog scale score decreased from 12.8 ± 8.4 after 3 weeks to 0.72 ± 2.2 after 6 months. From postoperative 3 weeks to 6 months, there were notable improvements in health and also in health-related quality of life; mean ± SD visual analog scale EuroQoL score increased from 72.1 ± 5 to 93.2 ± 4 and mean ± SD HR EuroQoL score from 0.60 ± 0.3 to 0.92 ± 0.2. At 6 months, mean scores of the eight dimensions of the short form SF-36 questionnaires had raised from baseline. Conclusion: The use of self-gripping Parietex ProGrip composite monofilament polyester mesh in Lichtenstein inguinal hernia repair is rapid, effective, simple, and safe. It is correlating with low postoperative groin pain and improved quality of life activities patients.